19,158 matching drops
#1459158 2026-09-22 15:17
punk6529 maybe's dive bar Reply #898371 2026-04-17 00:11
we really need to get our shit together this quarter on the cards that do something
Context from maybe #898341 2026-04-17 00:06
he rechallenged us to bring stuff to the real world through meme cards funding. so i was like, there is no way i'm letting someone else be the lock guy
punk6529 maybe's dive bar Reply #898196 2026-04-16 23:36
yes i hope so
Context from gpebbles #898188 2026-04-16 23:34
is that companies will be the future minters of the memes
punk6529 maybe's dive bar #898185 2026-04-16 23:33
instead of living dangerously with "buses"
punk6529 maybe's dive bar Reply #898184 2026-04-16 23:33
that is why I am staying safe typing things on a laptop all day
Context from gpebbles #898160 2026-04-16 23:29
we also prefer punk does not get hit by bus sir
punk6529 maybe's dive bar Reply #898175 2026-04-16 23:31
holy cow
Context from kristopher #898172 2026-04-16 23:31
I’m down 40 lbs
punk6529 maybe's dive bar #898168 2026-04-16 23:30
that you do not have any idea how complex it is
punk6529 maybe's dive bar #898167 2026-04-16 23:30
that biology is so absurdly complex
punk6529 maybe's dive bar #898165 2026-04-16 23:30
and then "is that really you, etc etc"
punk6529 maybe's dive bar #898164 2026-04-16 23:30
until we get silicon based brain backups etc
punk6529 maybe's dive bar #898163 2026-04-16 23:29
i mean if a ballistic missile falls on your head, you will also die in 2040
punk6529 maybe's dive bar #898161 2026-04-16 23:29
whatever "die" means in this context
punk6529 maybe's dive bar #898158 2026-04-16 23:28
imagine being the last generation in history to die
punk6529 maybe's dive bar #898157 2026-04-16 23:28
but we are going to be in the danger zone for extremely annoying outcomes
punk6529 maybe's dive bar #898156 2026-04-16 23:28
i just want to avoid something annoying if possible like dying 1 year before they can roll it back
punk6529 maybe's dive bar #898155 2026-04-16 23:28
if it does not happen, it also won't matter!
punk6529 maybe's dive bar Reply #898154 2026-04-16 23:28
it it happens, that won't matter!
Context from maybe #898147 2026-04-16 23:26
i'll be approaching 60 in the 2040s
punk6529 maybe's dive bar #898149 2026-04-16 23:26
then presumably a lot of constraints may not be real
punk6529 maybe's dive bar #898145 2026-04-16 23:26
i mean if we really truly get ASI this decade
punk6529 maybe's dive bar #898144 2026-04-16 23:26
but with low confidence in my prediction
punk6529 maybe's dive bar #898143 2026-04-16 23:26
i think we make it on the margin
punk6529 maybe's dive bar #898140 2026-04-16 23:25
which nobody yet knows if that in fact turns out to be a thing
punk6529 maybe's dive bar #898138 2026-04-16 23:25
if that turns out to be a thing
punk6529 maybe's dive bar #898136 2026-04-16 23:25
to have a chance at the "roll back to being a permanently jacked 28 yo"
punk6529 maybe's dive bar #898131 2026-04-16 23:25
so you need to stick around until the late 2030s? early 2040s?
punk6529 maybe's dive bar #898129 2026-04-16 23:24
the risk/reward of injecting is 'against'
punk6529 maybe's dive bar #898122 2026-04-16 23:24
are going to be stuck for a while
punk6529 maybe's dive bar #898121 2026-04-16 23:24
so us who will be middle aged during this period
punk6529 maybe's dive bar #898120 2026-04-16 23:23
but if you are 80 years old, other things are different
punk6529 maybe's dive bar #898118 2026-04-16 23:23
if you are not already 80 years old
punk6529 maybe's dive bar #898112 2026-04-16 23:23
how long would you want to see that operate
punk6529 maybe's dive bar #898108 2026-04-16 23:22
it is "you are getting younger and also not getting cancer"
punk6529 maybe's dive bar #898107 2026-04-16 23:22
it is not like it is "LDL is down"
punk6529 maybe's dive bar #898105 2026-04-16 23:22
and the endpoints are tough
punk6529 maybe's dive bar #898102 2026-04-16 23:22
we get the first candidates later this decade
punk6529 maybe's dive bar #898095 2026-04-16 23:22
closest is david sinclair's eye cells
punk6529 maybe's dive bar #898094 2026-04-16 23:21
there is not a single one currently live
punk6529 maybe's dive bar #898092 2026-04-16 23:21
they have high risk of being oncogenic
punk6529 maybe's dive bar #898091 2026-04-16 23:21
for large "rolling back the clock" genetic interventions
punk6529 maybe's dive bar #898088 2026-04-16 23:21
i don't think you will be able to avoid clinical trials